Aims: To date, it is largely unknown how body mass index (BMI), gestational weight (GW), and stored vitamin D (25(OH)D) levels change in the vitamin D-supplemented gestational diabetes mellitus (GDM) patients, irrespective of their pre-pregnancy BMI. Therefore, to study this association, a prospective systematic review and meta-analysis protocol is proposed here. Methods: Primarily, different databases (PubMed, Embase and Scopus) will be searched (without any limitation to date or language) for randomised parallel-arm trials comparing GW, BMI and stored vitamin D level in the body among GDM patients who were supplemented and not supplemented with vitamin D, besides their conventional GDM care. The study selection process and the consecutive risk of bias assessment will adhere to the PRISMA 2009 flow chart and the Cochrane collaboration’s guideline, respectively. These interventions’ effect on the respective outcomes will be compared by meta-analysis (along with an assessment of the statistical heterogeneity) when comparable data will be available from at least 4 studies. Subgroup analysis and Egger’s meta-regression will follow if an adequate number of trials are available. Narrative reporting will be considered when a quantitative comparison is not feasible for any of the outcomes. Conclusion: The proposed review aims to compare the BMI, GW, and 25(OH)D levels in the blood between the vitamin D supplemented and not supplemented GDM patients.
Int J Diabetes Metab

中文翻译：

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妊娠糖尿病患者补充维生素D与未接受补充剂的妊娠期体重，体重指数和血清维生素D水平变化的比较：系统评价和随机对照荟萃分析的方案试用版

目的：迄今为止，在补充维生素D的妊娠糖尿病（GDM）患者中，体重指数（BMI），妊娠体重（GW）和储存的维生素D（25（OH）D）水平如何变化尚不明确，不论他们的孕前BMI。因此，为了研究这种关联，本文提出了一种前瞻性的系统综述和荟萃分析方案。方法：首先，将搜索不同的数据库（PubMed，Embase和Scopus）（日期或语言没有任何限制），以比较在补充和不补充的GDM患者中体内GW，BMI和体内维生素D水平进行比较的随机平行试验除了常规的GDM护理外，还含有维生素D。研究选择过程和偏倚评估的连续风险将分别遵守PRISMA 2009流程图和Cochrane合作指南。当至少有4项研究可获得可比较的数据时，将通过荟萃分析（以及对统计异质性的评估）比较这些干预措施对各自结果的影响。如果有足够数量的试验，将进行亚组分析和Egger的Meta回归。结论：拟议的审查旨在比较补充维生素D和未补充维生素D的GDM患者之间的血液中BMI，GW和25（OH）D的水平。
Int J糖尿病代谢