Purpose In order to further understand genetically predisposing factors of gastric cancer, a retrospective study on 107 patients with gastric cancer was conducted. The family history of cancer cases was registered, in search of associations between gastric cancer and other cancer types. Materials and methods Within Stockholm County in Sweden, all patients previously diagnosed with gastric cancer and still alive were invited to participate in the study. Patients were asked to complete a questionnaire about their gastric cancer diagnosis and if any cancers had occurred in their family. A blood sample for DNA extraction was collected. The proportions of different cancer types in the relatives of the patients were compared to the general Swedish population in 1970 and 2010. Results Among first- and second-degree relatives to the index patients with gastric cancer, the frequency of uterine cancer as well as gastric cancer was significantly overrepresented compared to the general population in Sweden. The frequency of breast cancer was significantly lower. Conclusions There seems to be an increased risk of both gastric cancer and uterine cancer in the families of gastric cancer survivors, indicating a possible hereditary connection between these two cancer types.

中文翻译：

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瑞典胃癌患者的一级亲属患子宫癌的风险增加

目的为进一步了解胃癌的遗传易感因素，对107例胃癌患者进行回顾性研究。登记癌症病例的家族史，以寻找胃癌与其他癌症类型之间的关联。材料与方法 在瑞典斯德哥尔摩县，所有以前被诊断患有胃癌并仍然活着的患者都被邀请参加这项研究。患者被要求完成一份关于他们的胃癌诊断以及他们的家庭中是否发生过任何癌症的问卷。收集用于提取 DNA 的血样。将患者亲属中不同癌症类型的比例与 1970 年和 2010 年的瑞典普通人群进行了比较。结果 在胃癌指数患者的一级和二级亲属中，与瑞典的一般人群相比，子宫癌和胃癌的发病率明显偏高。乳腺癌的发病率显着降低。结论 胃癌幸存者的家庭中胃癌和子宫癌的风险似乎都增加了，这表明这两种癌症类型之间可能存在遗传联系。