Introduction. It is acknowledged that patients undergoing neurosurgery with neurological illness are at higher risk of lower extremity deep vein thrombosis (DVT). As an underlying life-threatening complication, the incidence and risk factors for high-risk patients with lower extremity deep vein thrombosis are still controversial in relative high-risk patients after neurosurgery. Materials and Methods. A total of 204 patients who underwent neurosurgery and were considered as a high-risk group of DVT according to times of stay in bed more than 3 days were enrolled in this study. We evaluated the lower extremity DVT by using Color Doppler Ultrasound System (CDUS). Clinical parameters of patients at the time of admission and postoperation were recorded and prepared for further analysis. Early predictive factors for postoperative lower extremity DVT were established. Diagnostic performance of predictive factors was evaluated by using receiver operating characteristic (ROC) curve analysis. Results. The overall incidence rate of DVT in 204 enrolled patients was 30.9%. Multivariate logistic regression indicated that hypertension (OR 3.159, 95% CI 1.465-6.816; ), higher postoperative D-dimer (OR 1.225, 95% CI 1.016-1.477; ), female (OR 0.174, 95% CI 0.054-0.568; ), and lower GCS score (OR 0.809, 95% CI 0.679-0.965; ) were independently associated with incidence of DVT in patients after neurosurgery. The logistic regression function (LR model) of these four independent risk factors had a better performance on diagnostic value of DVT in patients after neurosurgery. Conclusion. The combined factor was constructed by hypertension, postoperative D-dimer, gender, and GCS score, and it might be a more handy and reliable marker to stratify patients at risk of DVT after neurosurgery.

中文翻译：

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神经外科手术后相对高危患者下肢深静脉血栓形成的临床预测因素：一项回顾性研究。


介绍。众所周知，患有神经系统疾病而接受神经外科手术的患者发生下肢深静脉血栓（DVT）的风险较高。作为一种潜在的危及生命的并发症，高危患者下肢深静脉血栓的发生率和危险因素在相对高危患者神经外科术后的发生率和危险因素仍存在争议。材料和方法。本研究共纳入 204 例接受神经外科手术且根据卧床时间超过 3 天被视为 DVT 高危组的患者。我们使用彩色多普勒超声系统（CDUS）评估下肢 DVT。记录患者入院时和术后的临床参数并为进一步分析做好准备。建立了术后下肢 DVT 的早期预测因素。通过使用受试者工作特征（ROC）曲线分析来评估预测因素的诊断性能。结果。 204 例入组患者 DVT 总体发生率为 30.9%。多变量逻辑回归显示高血压（OR 3.159，95% CI 1.465-6.816； ），术后 D-二聚体较高（OR 1.225，95% CI 1.016-1.477； ），女性（OR 0.174，95% CI 0.054-0。568; ）和较低的 GCS 评分（OR 0.809，95% CI 0.679-0.965； ）与神经外科手术后患者 DVT 的发生率独立相关。这四个独立危险因素的逻辑回归函数（LR模型）对神经外科术后患者DVT的诊断价值有较好的表现。结论。该组合因素由高血压、术后 D-二聚体、性别和 GCS 评分构建，它可能是对神经外科术后 DVT 风险进行分层的更方便、更可靠的标志物。