Streptococcus gordonii is a commensal colonizer of oral cavity that initiates the formation of dental plaque. Oxyresveratrol is a natural purification from plants with antibacterial effects on various oral bacteria including Streptococcus mutans. The aim of this study was to investigate the effects of oxyresveratrol on S. gordonii. The basic viability, biofilm formation and cell aggregation of S. gordonii treated with oxyresveratrol were investigated. Oxyresveratrol dose-dependently inhibited the growth of S. gordonii in the absence of sucrose. However, in the presence of sucrose, it promoted biofilm formation under MIC. Both the biofilm formation and extracellular polysaccharides synthesis reached the maximum level at ½ MIC (250 μg/ml) oxyresveratrol. The gene expressions of abpA, abpB, scaA, gtfG, hsa, cshA, cshB, ccpA, srtA and sspB were upregulated when treated with 62.5 and 125 μg/ml oxyresveratrol. Eight of the ten genes were significantly upregulated at 250 μg/ml oxyresveratrol except abpB and sspB, which were downregulated at 250 μg/ml without significance. In conclusion, oxyresveratrol has dual-effects on S. gordonii. Considering its specific biofilm suppressive effect on S. mutans, it might be a candidate for bacterial interspecies modulator applied in caries prevention.

中文翻译：

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在蔗糖存在下，白藜芦醇可促进戈登链球菌的生物膜形成，细胞附着和聚集。

戈登链球菌是口腔的常见定居者，可引发牙菌斑的形成。Oxyresveratrol是从植物中天然纯化得到的，对各种口腔细菌（包括变形链球菌）具有抗菌作用。这项研究的目的是研究氧化白藜芦醇对戈登链球菌的影响。的基本可行性，生物膜形成和细胞聚集S.戈登与oxyresveratrol处理进行了研究。乙醛白藜芦醇剂量依赖性抑制戈登酵母的生长在没有蔗糖的情况下。然而，在蔗糖的存在下，它促进了MIC下生物膜的形成。在½MIC（250μg/ ml）氧白藜芦醇下，生物膜形成和细胞外多糖合成均达到最大水平。当分别用62.5和125μg/ ml氧白藜芦醇处理时，abpA，abpB，scaA，gtfG，hsa，cshA，cshB，ccpA，srtA和sspB的基因表达上调。除abpB和sspB外，十个基因中的八个基因在250 yg / ml的氧白藜芦醇中显着上调，而在250 yg / ml的下调中无意义。总之，氧白藜芦醇对戈登酵母有双重作用。考虑到其对变形链球菌的特异性生物膜抑制作用，它可能是用于预防龋齿的细菌种间调节剂的候选人。