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CXCL8high inflammatory B cells in the peripheral blood of patients with biliary atresia are involved in disease progression.
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-06-07 , DOI: 10.1111/imcb.12366 Yu Zhang 1 , Lin Zhou 2 , Guangxiang Gu 1 , Mingxuan Feng 1 , Xuping Ding 2 , Qiang Xia 1 , Liming Lu 2
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-06-07 , DOI: 10.1111/imcb.12366 Yu Zhang 1 , Lin Zhou 2 , Guangxiang Gu 1 , Mingxuan Feng 1 , Xuping Ding 2 , Qiang Xia 1 , Liming Lu 2
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Biliary atresia (BA), the most common cause of pediatric end‐stage liver disease, results from fibroinflammatory obstruction of the intrahepatic and extrahepatic bile ducts. The etiology of BA has been extensively studied, and inflammation and imbalanced immune system have been identified as the main pathogenesis of BA. B cells play roles in innate and adaptive immunity, but few studies have investigated the role of B cells in BA. This study aimed to elucidate the role of B cells in the development of BA. The percentage and numbers of total B cells (23.81 ± 11.14%，P < 0.0001, 1.22 ± 0.67 × 109 L–1, P = 0.0014) and immature B cells (25.33 ± 14.32%, P = 0.0013, 0.19 ± 0.20 × 109 L–1, P < 0.0001) were significantly increased in the peripheral blood of patients with BA and the number of total B cells was positively correlated with gamma‐glutamyl‐transpeptidase in the serum of BA. High C–X–C motif chemokine ligand 8 (CXCL8) levels were detected in the serum of patients with BA. As an important source of CXCL8, B cells from patients with BA secreted more CXCL8 into peripheral blood than those from control patients. Moreover, immature B cells can secrete more CXCL8 than mature B cells, and B cells secreted CXCL8 upon activation of the nuclear factor‐κB pathway. Taken together, the results revealed that B cells have a strong ability to secrete CXCL8, which is associated with the pathogenesis of BA, and exert a proinflammatory effect on the development of BA.
中文翻译：
胆道闭锁患者外周血CXCL8高炎症B细胞参与疾病进展。
胆道闭锁 (BA) 是小儿终末期肝病的最常见原因，由肝内和肝外胆管的纤维炎性阻塞引起。BA 的病因已被广泛研究，炎症和免疫系统失衡已被确定为 BA 的主要发病机制。B 细胞在先天免疫和适应性免疫中发挥作用，但很少有研究调查 B 细胞在 BA 中的作用。本研究旨在阐明 B 细胞在 BA 发展中的作用。B细胞总数（23.81 ± 11.14%，P < 0.0001, 1.22 ± 0.67 × 10 9 L –1 , P = 0.0014）和未成熟B细胞（25.33 ± 14.32%, P = 0.00103 × 0 ±0）的百分比和数量10 9升–1 , P < 0.0001)在BA患者外周血中显着增加，并且总B细胞数与BA血清中γ-谷氨酰转肽酶呈正相关。在 BA 患者的血清中检测到高 C-X-C 基序趋化因子配体 8（CXCL8）水平。作为 CXCL8 的重要来源，BA 患者的 B 细胞向外周血中分泌的 CXCL8 多于对照组患者。此外，未成熟的 B 细胞可以比成熟的 B 细胞分泌更多的 CXCL8，并且 B 细胞在核因子-κB 通路激活后分泌 CXCL8。综上所述，结果表明B细胞具有较强的分泌CXCL8的能力，这与BA的发病机制有关，并对BA的发展发挥促炎作用。
更新日期：2020-06-07
中文翻译：
胆道闭锁患者外周血CXCL8高炎症B细胞参与疾病进展。
胆道闭锁 (BA) 是小儿终末期肝病的最常见原因，由肝内和肝外胆管的纤维炎性阻塞引起。BA 的病因已被广泛研究，炎症和免疫系统失衡已被确定为 BA 的主要发病机制。B 细胞在先天免疫和适应性免疫中发挥作用，但很少有研究调查 B 细胞在 BA 中的作用。本研究旨在阐明 B 细胞在 BA 发展中的作用。B细胞总数（23.81 ± 11.14%，P < 0.0001, 1.22 ± 0.67 × 10 9 L –1 , P = 0.0014）和未成熟B细胞（25.33 ± 14.32%, P = 0.00103 × 0 ±0）的百分比和数量10 9升–1 , P < 0.0001)在BA患者外周血中显着增加，并且总B细胞数与BA血清中γ-谷氨酰转肽酶呈正相关。在 BA 患者的血清中检测到高 C-X-C 基序趋化因子配体 8（CXCL8）水平。作为 CXCL8 的重要来源，BA 患者的 B 细胞向外周血中分泌的 CXCL8 多于对照组患者。此外，未成熟的 B 细胞可以比成熟的 B 细胞分泌更多的 CXCL8，并且 B 细胞在核因子-κB 通路激活后分泌 CXCL8。综上所述，结果表明B细胞具有较强的分泌CXCL8的能力，这与BA的发病机制有关，并对BA的发展发挥促炎作用。
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