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Natural Xanthone α-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-κB Signaling Pathway.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-28 , DOI: 10.1002/mnfr.202000096 Huifeng Guan 1 , Jiabing Li 1 , Xiaofang Tan 1 , Shenying Luo 1 , Yangdan Liu 1 , Yiwen Meng 1 , Baichuan Wu 1 , Yan Zhou 1 , Yang Yang 1 , Hongzhuan Chen 2 , Lina Hou 1 , Yu Qiu 1 , Juan Li 1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-28 , DOI: 10.1002/mnfr.202000096 Huifeng Guan 1 , Jiabing Li 1 , Xiaofang Tan 1 , Shenying Luo 1 , Yangdan Liu 1 , Yiwen Meng 1 , Baichuan Wu 1 , Yan Zhou 1 , Yang Yang 1 , Hongzhuan Chen 2 , Lina Hou 1 , Yu Qiu 1 , Juan Li 1
Affiliation
The effect of α‐mangostin (α‐M), a polyphenolic xanthone isolated from mangostin, on lipopolysaccharide (LPS)‐induced microglial activation and memory impairment is explored. The possible underlying mechanisms are also investigated.
中文翻译:
天然黄酮α-Mangostin通过阻断TAK1 /NF-κB信号通路来抑制LPS诱导的小胶质细胞炎症反应和记忆障碍。
研究了从芒果中分离出的多酚类黄酮α-mangostin(α-M)对脂多糖(LPS)诱导的小胶质细胞活化和记忆障碍的影响。还研究了可能的潜在机制。
更新日期:2020-06-28
中文翻译:
天然黄酮α-Mangostin通过阻断TAK1 /NF-κB信号通路来抑制LPS诱导的小胶质细胞炎症反应和记忆障碍。
研究了从芒果中分离出的多酚类黄酮α-mangostin(α-M)对脂多糖(LPS)诱导的小胶质细胞活化和记忆障碍的影响。还研究了可能的潜在机制。