Review: amino acid biosynthesis as a target for herbicide development.,Pest Management Science

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Review: amino acid biosynthesis as a target for herbicide development.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-06-07 , DOI: 10.1002/ps.5943
Cody J Hall ₁ , Emily Rr Mackie ₁ , Anthony R Gendall ₂ , Matthew A Perugini ₁ , Tatiana P Soares da Costa ₁

Affiliation

There are three amino acid biosynthesis pathways that are targeted by current herbicides, namely those leading to the production of aromatic amino acids, branched chain amino acids and glutamine. However, their efficacy is diminishing as a result of the increasing number of resistant weeds. Indeed, resistance to most classes of herbicides is on the rise, posing a significant threat to the utility of current herbicides to sustain effective weed management. This review provides an overview of potential herbicide targets within amino acid biosynthesis that remain unexploited commercially, and recent inhibitor discovery efforts. Despite contemporary approaches to herbicide discovery, such as chemical repurposing and the use of omics technologies, there have been no new products introduced to the market that inhibit amino acid biosynthesis over the past three decades. This highlights the chasm that exists between identifying a potent inhibitor and introducing a commercial herbicide. The unpredictability of a mode of action at the systemic level, as well as poor physicochemical properties, often contribute to a lack of progression beyond the target inhibition stage. Nevertheless, it will be important to overcome these obstacles for the development of new herbicides to protect our agricultural industry and ensure food security for an increasing world population. © 2020 Society of Chemical Industry

中文翻译：

综述：氨基酸生物合成作为除草剂开发的目标。

当前的除草剂靶向三种氨基酸生物合成途径，即导致产生芳香族氨基酸，支链氨基酸和谷氨酰胺的那些。然而，由于抗性杂草数量的增加，它们的功效正在降低。确实，对大多数除草剂的抗药性正在上升，这对当前除草剂用于维持有效杂草处理的效用构成了重大威胁。这篇综述概述了氨基酸生物合成中潜在的除草剂靶标，这些靶标在商业上尚未得到开发，以及最近发现的抑制剂。尽管采用了当代的除草剂发现方法，例如化学用途改变和组学技术的使用，在过去的三十年中，没有新的产品抑制氨基酸的生物合成。这突显了在确定有效抑制剂与引入商业除草剂之间存在的鸿沟。全身性作用方式的不可预测性以及较差的理化性质通常会导致缺乏靶抑制阶段后的进展。尽管如此，克服这些阻碍发展新型除草剂的障碍对于保护我们的农业产业并确保不断增长的世界人口的粮食安全至关重要。©2020化学工业协会以及较差的理化特性，通常会导致缺乏靶抑制阶段以外的疾病进展。尽管如此，克服这些阻碍发展新型除草剂的障碍对于保护我们的农业产业并确保不断增加的世界人口的粮食安全至关重要。©2020化学工业协会以及理化性质较差，通常会导致缺乏超出目标抑制阶段的进展。尽管如此，克服这些阻碍发展新型除草剂的障碍对于保护我们的农业产业并确保不断增长的世界人口的粮食安全至关重要。©2020化学工业协会

更新日期：2020-06-07

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