Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode.,Pest Management Science

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Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-06-07 , DOI: 10.1002/ps.5951
Philippe Desbordes ₁ , Bernd Essigmann ₁ , Stephanie Gary ₁ , Oliver Gutbrod ₂ , Michael Maue ₂ , Hans-Georg Schwarz ₂

Affiliation

Succinate dehydrogenase inhibitors (SDHIs) have played a crucial role in disease control to protect cereals as well as fruit and vegetables for more than a decade. Isoflucypram, the first representative of a newly installed subclass of SDHIs inside the Fungicide Resistance Action Committee (FRAC) family of complex II inhibitors, offers unparalleled long‐lasting efficacy against major foliar diseases in cereals. Herein we report the chemical optimization from early discovery towards isoflucypram and the first hypothesis of its altered binding mode in the ubiquinone binding site of succinate dehydrogenase. © 2020 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

中文翻译：

新型琥珀酸脱氢酶抑制剂杀菌剂亚类的首个代表异氟普兰：其化学发现和异常的结合方式。

琥珀酸脱氢酶抑制剂（SDHIs）在疾病控制中起到了至关重要的作用，以保护谷物以及水果和蔬菜超过十年。Isoflucypram是复合物II抑制剂的抗真菌药行动委员会（FRAC）系列中新安装的SDHIs子类的第一个代表，对谷物中的主要叶面疾病具有无与伦比的持久功效。在这里，我们报道了从早期发现到异氟吡兰的化学优化及其在琥珀酸脱氢酶的泛醌结合位点改变结合方式的第一个假设。©2020作者。John Wiley＆Sons Ltd代表化学工业协会出版的《害虫管理科学》。

更新日期：2020-06-07

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