Fetal inflammatory signals can be propagated to maternal tissues to initiate labor via exosomes (extracellular vesicles; 30‐150 nm). We tested the hypothesis that fetal membrane cells exposed to infectious and inflammatory mediators associated with preterm birth (PTB) produce exosomes with distinct protein cargo contents indicative of underlying pathobiology.

中文翻译：

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胎膜细胞外囊泡分析揭示了体外感染和炎症诱导的不同途径。

胎儿炎症信号可以通过外泌体（细胞外囊泡；30-150 nm）传播到母体组织以启动分娩。我们测试了胎儿膜细胞暴露于与早产 (PTB) 相关的感染性和炎症性介质产生外泌体的假设，该外泌体具有不同的蛋白质货物含量，表明潜在的病理生物学。