T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8⁺ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

中文翻译：

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在CD8 +胸腺细胞中指导记忆。

T细胞有时可以在不遇到外来抗原的情况下获得记忆细胞的特性。米勒等。现在表明，这种“记忆表型”（MP）CD8 ⁺ T细胞的发育始于在胸腺中对自身配体的识别，并在周围组织中完成。这些细胞在感染过程中反应迅速，并浸润肿瘤，在那里它们表达大量的PD-1。