For decades, limb development has been a paradigm of three-dimensional patterning. Moreover, as the limb muscles and the other tissues of the limb’s musculoskeletal system arise from distinct developmental sources, it has been a prime example of integrative morphogenesis and cross-tissue communication. As the limbs grow, all components of the musculoskeletal system (muscles, tendons, connective tissue, nerves) coordinate their growth and differentiation, ultimately giving rise to a functional unit capable of executing elaborate movement. While the molecular mechanisms governing global three-dimensional patterning and formation of the skeletal structures of the limbs has been a matter of intense research, patterning of the soft tissues is less understood. Here, we review the development of limb muscles with an emphasis on their interaction with other tissue types and the instructive roles these tissues play. Furthermore, we discuss the role of adult correlates of these embryonic accessory tissues in muscle regeneration.

几十年来，肢体发育一直是三维图案的范例。此外，由于肢体肌肉和肢体肌肉骨骼系统的其他组织来自不同的发育来源，因此它已成为整合形态发生和跨组织交流的主要例子。随着四肢的成长，肌肉骨骼系统的所有组成部分（肌肉，肌腱，结缔组织，神经）协调其生长和分化，最终形成了能够执行精细运动的功能单元。尽管支配全局三维构图和四肢骨骼结构形成的分子机制是一项深入研究，但对软组织的构图知之甚少。这里，我们回顾了肢体肌肉的发展，重点是它们与其他组织类型的相互作用以及这些组织所起的指导作用。此外，我们讨论了这些胚胎附属组织的成年关联在肌肉再生中的作用。