Current treatment for diabetic wounds remains a major clinical challenge. The present work was aimed at the fabrication of a novel scaffold consisting of curcumin and Gymnema sylvestre incorporated graphene oxide-polyhydroxybutyrate‑sodium alginate (GO-PHB-SA-CUR&GS) composite as an extracellular matrix platform. The novel graphene oxide-polyhydroxybutyrate‑sodium alginate composite scaffold was prepared by solution casting, into which curcumin and Gymnema sylvestre was incorporated to improve healing of normal and diabetic wounds for better tissue regeneration application. The GO-PHB-SA-CUR&GS composite was evaluated for particle size, surface charge (zeta potential), crystalline nature (XRD), and morphology (SEM). In-vitro studies with normal and diabetic fibroblast cells confirmed that the GO-PHB-SA-CUR&GS composite showed good biocompatible characteristics in terms of increased migration of wounded cells. Thus, the GO-PHB-SA-CUR&GS composite could significantly accelerate the healing of normal and diabetic wounds.

当前糖尿病伤口的治疗仍然是主要的临床挑战。本工作旨在制造一种新型支架，该支架由姜黄素和匙Gym藤组成，并掺入氧化石墨烯-聚羟基丁酸酯-海藻酸钠（GO-PHB-SA-CUR＆GS）复合物作为细胞外基质平台。通过溶液流延制备新型氧化石墨烯-聚羟基丁酸酯-海藻酸钠复合支架，其中加入姜黄素和匙Gym藤以改善正常和糖尿病伤口的愈合，从而更好地应用组织再生。对GO-PHB-SA-CUR＆GS复合材料的粒度，表面电荷（ζ电位），结晶性（XRD）和形态（SEM）进行了评估。体外对正常和糖尿病成纤维细胞的研究证实，GO-PHB-SA-CUR＆GS复合材料在伤口细胞迁移增加方面显示出良好的生物相容性。因此，GO-PHB-SA-CUR＆GS复合材料可以显着加速正常和糖尿病伤口的愈合。