Adult stem cells sustain tissue homeostasis throughout life and provide an important reservoir of cells capable of tissue repair in response to stress and tissue damage. Age-related changes to stem cells and/or the specialized niches that house them have been shown to negatively impact stem cell maintenance and activity. In addition, metabolic inputs have surfaced as another crucial layer in the control of stem cell behavior (Chandel et al., 2016; Folmes and Terzic, 2016; Ito and Suda, 2014; Mana et al., 2017; Shyh-Chang and Ng, 2017). Here, we will present a brief review of how lipid metabolism influences adult stem cell behavior under homeostatic conditions and speculate on how changes in lipid metabolism may impact stem cell ageing. This review considers the future of lipid metabolism research in stem cells, with the long-term goal of identifying mechanisms that could be targeted to counter or slow the age-related decline in stem cell function.

成体干细胞在整个生命过程中维持组织稳态，并提供了重要的细胞储备，能够响应压力和组织损伤进行组织修复。干细胞和/或容纳它们的专用壁ni的年龄相关变化已显示出对干细胞的维持和活性产生负面影响。此外，代谢输入已成为控制干细胞行为的另一个关键层（Chandel等人，2016; Folmes和Terzic，2016; Ito和Suda，2014; Mana等人，2017; Shyh-Chang和Ng ，2017）。在这里，我们将简要介绍脂质代谢如何在稳态条件下影响成年干细胞的行为，并推测脂质代谢的变化如何影响干细胞的衰老。这篇评论考虑了干细胞脂质代谢研究的未来，