The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage. In addition, YAP/TAZ are promising targets for regenerative medicine, as artificially increasing YAP/TAZ activity can be used to stimulate tissue regeneration, even in tissues that otherwise have little ability to regenerate. We will summarize here how YAP/TAZ could be used in regenerative medicine and how these two transcriptional regulators have been linked to aging so far.

中文翻译：

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河马信号再生和衰老。

两个转录共激活因子YAP / TAZ充当河马途径的下游转化子。最近的研究表明，这两个转录调节因子对于生物体至关重要，以便在组织受损时诱导再生反应。此外，YAP / TAZ是再生医学的有希望的靶标，因为人工增加的YAP / TAZ活性可用于刺激组织再生，即使在原本再生能力差的组织中也是如此。我们将在这里总结如何在再生医学中使用YAP / TAZ，以及迄今为止如何将这两个转录调节因子与衰老联系起来。