Statistical surveys of COVID-19 patients indicate, against all common logic, that people who smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than non-smokers. This suggests that nicotine may have some preventive or modulatory effect on the inflammatory response in the lungs. Because it is known that the response to, and resolution of the SARS-CoV-2 infection depends mainly on the lung macrophages, we discuss the recent scientific findings, which may explain why and how nicotine may modulate lung macrophage response during COVID-19 infection.

中文翻译：

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尼古丁如何抑制肺部细胞因子风暴并预防或减轻 COVID-19 感染的严重程度？

对 COVID-19 患者的统计调查表明，与所有常见逻辑相反，吸烟者比不吸烟者更不容易受到感染和/或表现出不太严重的呼吸道症状。这表明尼古丁可能对肺部炎症反应有一定的预防或调节作用。由于众所周知，对 SARS-CoV-2 感染的反应和解决主要取决于肺巨噬细胞，因此我们讨论最近的科学发现，这可能解释尼古丁在 COVID-19 感染期间调节肺巨噬细胞反应的原因和方式。