Context

The aging phenotype is quite heterogeneous, being the result of the capability of each individual to successfully or unsuccessfully response to stressors. The reduction of homeostatic reserve characterizing aging is accompanied by a remodeling of the endocrine system. Frailty has been indicated as a promising way for capturing the physiological decline as well as the biological aging of the individuals. In particular, the Frailty Index (FI), based on the assumption that health deficits tend to accumulate with aging, represents a quantitative measure of extreme interest.

Objective

The study aims to correlate the thyroid hormone levels with FI in a population of centenarians and their offspring to capture the effects of thyroid remodeling in extreme longevity.

Study design

The study described 593 well-characterized Italian subjects, including 180 centenarians, as well as 276 centenarian's offspring and 137 age-matched controls.

Results

FT3 levels and FT3/FT4 ratio were significantly lower (p < 0.001) and TSH levels higher (p < 0.001) in centenarians compared to the other groups, analysing both overall subjects and excluding subjects with hormone levels out of the normal ranges. In overall centenarians, we observed a negative correlation between FI and FT3 (ρ: −0.281, p < 0.001), FT3/FT4 (ρ: −0.344, p < 0.001) and TSH (ρ: −0.223, p 0.003) and a positive association between FI and FT4 (ρ: 0.189, p = 0.001). In centenarians with hormone levels within the normal ranges, similar negative correlations were observed between FI and FT3 (ρ: −0.201, p = 0.02) and FT3/FT4 (ρ: −0.264, p = 0.002). In this sub-analysis, FI positively correlated with FT4 and age (ρ: 0.167, p = 0.05; ρ: 0.219, p = 0.005, respectively). Conversely, no significant correlations were observed between hormone levels and FI in offspring and controls.

Conclusions

We found an association between thyroid hormone levels and frailty in centenarians, underlying the significant role of thyroid in the aging process and longevity.

中文翻译：

---

寿命极长的人的甲状腺激素和虚弱。

语境

衰老表型是非常异质的，这是每个人对压力源成功或不成功反应的能力的结果。表征衰老的体内稳态储备的减少伴随着内分泌系统的重塑。脆弱已经被认为是捕捉个体生理衰退和生物衰老的一种有前途的方式。尤其是，脆弱指数（FI）基于健康赤字会随着年龄增长而累积的假设，是对极端利益的定量衡量。

目的

这项研究旨在将百岁老人及其后代中甲状腺激素水平与FI关联起来，以捕捉甲状腺重塑对长寿的影响。

学习规划

该研究描述了593个特征明确的意大利受试者，其中包括180个百岁老人，以及276个百岁老人的后代和137个年龄相匹配的对照。

结果

与其他组相比，百岁老人中的FT3水平和FT3 / FT4比率显着较低（p <0.001），TSH水平较高（p <0.001），同时分析了总体受试者并排除了激素水平超出正常范围的受试者。在整个百岁老人中，我们观察到FI和FT3（ρ：-0.281，p <0.001），FT3 / FT4（ρ：-0.344，p <0.001）和TSH（ρ：-0.223，p 0.003）和a之间呈负相关。 FI和FT4之间呈正相关（ρ：0.189，p = 0.001）。在激素水平在正常范围内的百岁老人中，在FI和FT3（ρ：-0.201，p = 0.02）和FT3 / FT4（ρ：-0.264，p = 0.002）之间观察到相似的负相关。在此子分析中，FI与FT4和年龄呈正相关（分别为：ρ：0.167，p = 0.05；ρ：0.219，p = 0.005）。反过来，

结论

我们发现百岁老人的甲状腺激素水平与虚弱之间存在关联，这暗示了甲状腺在衰老过程和长寿中的重要作用。