Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5.0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.

对外源或内源性刺激敏感的纳米载体已成为目标药物递送的一种有吸引力的替代方法，无机二氧化硅介孔纳米颗粒（MNs）在新一代无毒且可调节的纳米载体的开发中起着核心作用。合成了包含发光硅量子点（SiQD）并被MNs功能化的敏感纳米载体（NANO1），并加载了阿霉素（DOX）。NANO1纳米粒子的尺寸为74±10 nm，DOX的负载百分比约为。43％。作为对照样品，还合成了不含SiQD的类似纳米载体（NANO2），并装有DOX。在PBS中进行的释放曲线研究显示出强大的NANO1@DOX pH依赖的行为，pH 5.0有利于DOX释放至约ca的百分比。70％。在结肠的人细胞系中评估了游离和载有DOX的纳米载体的细胞毒性评估，发现游离药物和载有纳米颗粒的药物都具有浓度依赖性。