In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing Cu_2-xSe-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo. The amorphous form of Cu_2-xSe and the catalytic effect of Au benefit the OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional OH. The plasmonic electrons of Au facilitate the conversion from Cu²⁺ to Cu⁺. Both Cu_2-xSe and Au contributes to the efficient photothermal conversion, further promoting the reactions. As a result, the H₂O₂ utilization rate is largely increased, and remarkable generation of reactive oxygen species is achieved by cell endogenous H₂O₂ in vitro/vivo. A competent tumor inhibition effect is afforded, with high-contrast multimodal imaging. This work opens up the route synergistically integrating photothermal therapy with chemodynamic therapy and photocatalytic therapy into tri-combination antitumor therapy, simply by heterojunction of semiconductor and noble metal.

由肿瘤微环境（TME）激活的体内化学反应对于抗肿瘤治疗特别有希望。在此，采用Cu _2-x Se-Au Janus纳米颗粒（NPs），在体外/体内证明了光热转化配位的Fenton样和光催化反应。Cu _2-x Se的无定形形式和Au的催化作用有利于OH的产生，而Janus NPs的光诱导电子空穴分离产生了额外的OH。Au的等离子体电子促进了Cu ²⁺向Cu ⁺的转化。铜_2-x硒和金有助于有效的光热转化，进一步促进反应。结果，H ₂ O ₂利用率大大提高，并且通过细胞内源性H ₂ O ₂ 在体外/体内实现了显着的活性氧生成。高对比度的多模态成像可提供有效的肿瘤抑制作用。这项工作开辟了将光热疗法与化学动力学疗法和光催化疗法协同地整合到三组合抗肿瘤疗法中的途径，仅通过半导体和贵金属的异质结即可。