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Male adnexal tumor of probable Wolffian origin: a new entity in males similar to female adnexal tumor of probable Wolffian origin.
Virchows Archiv ( IF 3.4 ) Pub Date : 2020-06-06 , DOI: 10.1007/s00428-020-02852-2
Christina Kanaan 1 , Catherine Genestie 1 , Pierre-Alexandre Just 2 , Mathilde Sibony 2
Affiliation  

Female adnexal tumor of probable Wolffian origin is a rare tumor listed in the 2016 WHO classification of the female reproductive tract. It does not have a WHO-recognized counterpart in the male urogenital tract. However, some cases of male adnexal tumors have been described in the literature. We present the case of a 41-year-old male who presented with a 2-cm nodule in the testicle. LDH, HCG, and AFP blood levels were normal. Gross examination showed an intratesticular, whitish, microcystic, firm, and encapsulated nodule of 2 cm. Microscopically, the tumor was well circumscribed, solid, and microcystic. In the solid areas, cells were fusiform or polygonal with an eosinophilic pale cytoplasm and a regular oval nucleus. Cysts were surrounded by a fibromuscular stroma and lined by a single layer of cylindrical epithelium, with apical cilia. On immunohistochemistry, tumor cells expressed AE1/AE3 and vimentin and were negative for calretinin, epithelial membrane antigen (EMA), and inhibin. All the differential diagnoses at this localization being ruled out, the tumor was compared to a female adnexal tumor of probable Wolffian origin. Both tumors had approximately the same morphological and immunohistochemical profile. Naming our tumor MATPWO is therefore justified, but it remains of a probable origin because further studies need to be performed in order to certify this hypothesis.



中文翻译:

可能起源于沃尔夫的男性附件瘤:男性中的一个新实体,类似于可能起源于沃尔夫的女性附件瘤。

可能是Wolffian起源的女性附件肿瘤是2016年WHO女性生殖道分类中列出的罕见肿瘤。在男性泌尿生殖道中没有WHO认可的对应物。但是,文献中已经描述了一些男性附件肿瘤的病例。我们介绍了一个41岁男性在睾丸中出现2厘米结节的病例。LDH,HCG和AFP血液水平正常。大体检查显示2 cm的睾丸内,发白,微囊性,结实和包囊结节。在显微镜下,肿瘤被良好地界定,实体和微囊性。在实心区域,细胞呈梭形或多边形,具有嗜酸性的淡细胞质和规则的椭圆形核。囊肿被纤维肌基质包围,并被单层的圆柱状上皮和顶端的纤毛所衬。在免疫组织化学上,肿瘤细胞表达AE1 / AE3和波形蛋白,而钙调蛋白,上皮膜抗原(EMA)和抑制素均呈阴性。排除了该定位的所有鉴别诊断,将肿瘤与可能为沃尔夫芬起源的女性附件肿瘤进行了比较。两种肿瘤都具有大致相同的形态和免疫组织化学特征。因此,给我们的肿瘤MATPWO命名是合理的,但它仍可能是起源,因为需要进行进一步的研究以证实这一假设。两种肿瘤都具有大致相同的形态和免疫组化谱。因此,给我们的肿瘤MATPWO命名是合理的,但它仍可能是起源,因为需要进行进一步的研究以证实这一假说。两种肿瘤都具有大致相同的形态和免疫组织化学特征。因此,给我们的肿瘤MATPWO命名是合理的,但它仍可能是起源,因为需要进行进一步的研究以证实这一假设。

更新日期:2020-06-06
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