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The role of anthocyanins as antidiabetic agents: from molecular mechanisms to in vivo and human studies.
Journal of Physiology and Biochemistry ( IF 3.7 ) Pub Date : 2020-06-06 , DOI: 10.1007/s13105-020-00739-z
Francisco Les 1, 2 , Guillermo Cásedas 1 , Carlota Gómez 1 , Cristina Moliner 1 , Marta Sofía Valero 2, 3 , Víctor López 1, 2, 4
Affiliation  

Diabetes mellitus is a chronic metabolic disease characterized by high blood glucose concentration. Nowadays, type 2 diabetes or insulin resistant diabetes is the most common diabetes, mainly due to unhealthy lifestyle. Healthy habits like appropriate nutritional approaches or the consumption of certain natural products or food supplements have been suggested as non-pharmacological strategies for the treatment and prevention of type 2 diabetes. Some of the main bioactive compounds from plant foods are polyphenols, important mainly for their antioxidant capacity in oxidative stress conditions and ageing. Anthocyanins are polyphenols of the flavonoid group, which act as pigments in plants, especially in fruits such as berries. A search of in vitro, in vivo and human studies in relation with antidiabetic properties of anthocyanins has been performed in different electronic databases. Results of this review demonstrate that these compounds have the ability to inhibit different enzymes as well as to influence gene expression and metabolic pathways of glucose, such as AMPK, being able to modulate diabetes and other associated disorders, as hyperlipidaemia, overweight, obesity and cardiovascular diseases. Additionally, human interventional studies have shown that high doses of anthocyanins have potential in the prevention or treatment of type 2 diabetes; nevertheless, anthocyanins used in these studies should be standardized and quantified in order to make general conclusions about its use and to claim benefits for the human population.



中文翻译:

花青素作为抗糖尿病药物的作用:从分子机制到体内和人体研究。

糖尿病是一种以高血糖为特征的慢性代谢性疾病。如今,2型糖尿病或胰岛素抵抗糖尿病是最常见的糖尿病,主要是由于不健康的生活方式。健康习惯,如适当的营养方法或食用某些天然产品或食品补充剂,已被建议作为治疗和预防 2 型糖尿病的非药物策略。植物性食物中的一些主要生物活性化合物是多酚,主要是因为它们在氧化应激条件和老化条件下的抗氧化能力很重要。花青素是类黄酮组的多酚,在植物中充当色素,尤其是在浆果等水果中。体外研究,已在不同的电子数据库中进行了与花青素抗糖尿病特性相关的体内和人体研究。本综述的结果表明,这些化合物能够抑制不同的酶,并影响葡萄糖的基因表达和代谢途径,如 AMPK,能够调节糖尿病和其他相关疾病,如高脂血症、超重、肥胖和心血管疾病。疾病。此外,人体干预研究表明,高剂量的花青素具有预防或治疗 2 型糖尿病的潜力;尽管如此,这些研究中使用的花青素应该标准化和量化,以便对其使用做出一般性结论并声称对人类有益。本综述的结果表明,这些化合物能够抑制不同的酶,并影响葡萄糖的基因表达和代谢途径,如 AMPK,能够调节糖尿病和其他相关疾病,如高脂血症、超重、肥胖和心血管疾病。疾病。此外,人体干预研究表明,高剂量的花青素具有预防或治疗 2 型糖尿病的潜力;尽管如此,这些研究中使用的花青素应该标准化和量化,以便对其使用做出一般性结论并声称对人类有益。本综述的结果表明,这些化合物能够抑制不同的酶,并影响葡萄糖的基因表达和代谢途径,如 AMPK,能够调节糖尿病和其他相关疾病,如高脂血症、超重、肥胖和心血管疾病。疾病。此外,人体干预研究表明,高剂量的花青素具有预防或治疗 2 型糖尿病的潜力;尽管如此,这些研究中使用的花青素应该标准化和量化,以便对其使用做出一般性结论并声称对人类有益。能够调节糖尿病和其他相关疾病,如高脂血症、超重、肥胖和心血管疾病。此外,人体干预研究表明,高剂量的花青素具有预防或治疗 2 型糖尿病的潜力;尽管如此,这些研究中使用的花青素应该标准化和量化,以便对其使用做出一般性结论并声称对人类有益。能够调节糖尿病和其他相关疾病,如高脂血症、超重、肥胖和心血管疾病。此外,人体干预研究表明,高剂量的花青素具有预防或治疗 2 型糖尿病的潜力;尽管如此,这些研究中使用的花青素应该标准化和量化,以便对其使用做出一般性结论并声称对人类有益。

更新日期:2020-06-06
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