Sand flies (Diptera: Psychodidae: Phlebotominae) are the only proven vectors of leishmaniasis. Leishmania parasites develop and differentiate in the sand fly gut where they reside alongside the vector’s gut bacteria. Gut bacteria are important to sand fly’s nutrition, oviposition, and defence against pathogens. In vectors, gut bacteria also influence vector competence. However, the link between specific bacterial taxa and sand fly vector susceptibility is poorly documented. In this review, we investigated current published data on bacterial communities in sand flies and provide a better understanding of how gut bacteria influence sand fly-Leishmania interactions. Understanding sand fly-bacteria-Leishmania interactions will provide new targets in vector control and Leishmania-transmission blocking approaches.

中文翻译：

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沙蝇肠道中的细菌组成和多样性：对利什曼原虫和沙蝇发育的影响

沙蝇（双翅目：Psychodidae：Phlebotominae）是唯一经证实的利什曼病载体。利什曼原虫寄生虫在沙蝇肠道中发育和分化，它们与载体的肠道细菌一起存在。肠道细菌对沙蝇的营养、产卵和抵御病原体很重要。在载体中，肠道细菌也会影响载体能力。然而，特定细菌分类群与白蛉病媒易感性之间的联系鲜有记载。在这篇综述中，我们调查了当前发表的关于白蛉细菌群落的数据，并更好地了解肠道细菌如何影响白蛉-利什曼原虫的相互作用。了解沙蝇-细菌-利什曼原虫的相互作用将为病媒控制和利什曼原虫传播阻断方法提供新的目标。