28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3 β ,19 β ,28-oleantriol were tested in vitro for cytotoxicity against 60 cell lines of 9 human tumor types. Melanoma SK-MEL-5 and CNS SNB-75 cancer cells died in the presence of 3- or 4-pyridylidene derivatives of 28-oxo-allobetulone. 3 β ,19 β ,28-Oleantriol possessed selective cytotoxicity against CNS cancer cell line SNB-75.

中文翻译：

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28-Oxo-Allobetulone 衍生物的合成和细胞毒性

28-Oxo-allobetulone 衍生物是新合成的或较早通过修饰 A 环（3-和 4-吡啶、糠基、氮杂、内酰胺、喹诺酮、螺吲哚、吡唑、异恶唑和四恶烷衍生物）和 3 β ,19 β 制备的衍生物在体外测试了 ,28-齐墩果三醇对 9 种人类肿瘤类型的 60 种细胞系的细胞毒性。黑色素瘤 SK-MEL-5 和 CNS SNB-75 癌细胞在 28-oxo-allobetulone 的 3-或 4-吡啶衍生物存在下死亡。3 β ,19 β ,28-Oleantriol 对 CNS 癌细胞系 SNB-75 具有选择性细胞毒性。