This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. This study included a total of 154 patients (84 with PCOS, 70 healthy volunteers). Metabolic and endocrine parameters and arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper serum levels of the patients were compared between the groups. Considering the action mechanism of toxic metals, serum malondialdehyde (MDA), superoxide dismutase (SOD), serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor-alpha (TNFα), and high-sensitivity C-reactive protein (HsCRP) levels were determined. Serum TAS (p = 0.002), OSI (p = 0.006), SOD (p = 0.006), zinc (p = 0.010), and copper (p = 0.030) values were statistically lower whereas TOS (p = 0.008), MDA (p < 0.001), HsCRP (p < 0.001), TNFα (p < 0.001), antimony (p < 0.001), cadmium (p < 0.001), lead (p < 0.001), and mercury (p < 0.001) levels were significantly higher in the PCOS group than those determined in the control group. Antimony was positively correlated with fasting glucose (FG) and HOMA-IR while cadmium, in addition to FG and HOMA-IR, positively correlated with insulin and lead had a positive correlation only with FG (p < 0.05). Also, these three heavy metals correlated positively with some oxidative system and inflammatory parameters and negatively with the antioxidant system parameters (p < 0.05). In conclusion, heavy metal exposures in PCOS may be related to insulin resistance and hirsutism through oxidative and inflammatory mechanisms. This approach can be used to identify the risky patient group and to develop new treatment modalities.

这项研究旨在确定多囊卵巢综合征（PCOS）的代谢和内分泌病理学与砷，铬，镉，铅，汞，锑，锌和铜的水平之间的关系，以评估这些有毒金属与炎症的关系。 /氧化参数。该研究共包括154位患者（84位PCOS患者，70位健康志愿者）。比较两组患者的代谢和内分泌参数以及砷，铬，镉，铅，汞，锑，锌和铜的血清水平。考虑到有毒金属，血清丙二醛（MDA），超氧化物歧化酶（SOD），血清总抗氧化剂状态（TAS），总氧化剂状态（TOS），氧化应激指数（OSI），肿瘤坏死因子-α（TNFα）的作用机理，测定高敏C反应蛋白（HsCRP）的水平。血清TAS（p = 0.002），OSI（p = 0.006），SOD（p = 0.006），锌（p = 0.010）和铜（p = 0.030）值在统计学上较低，而TOS（p = 0.008），MDA（p <0.001 ），HsCRP（p <0.001），TNFα（p <0.001），锑（p <0.001），镉（p <0.001），铅（p <0.001）和汞（p<0.001）水平在PCOS组中明显高于对照组。锑与空腹血糖（FG）和HOMA-IR正相关，而镉除FG和HOMA-IR外与胰岛素呈正相关，铅仅与FG正相关（p <0.05）。而且，这三种重金属与某些氧化系统和炎症参数呈正相关，与抗氧化系统参数呈负相关（p <0.05）。总之，PCOS中重金属的暴露可能通过氧化和炎症机制与胰岛素抵抗和多毛症有关。该方法可用于识别有风险的患者组并开发新的治疗方式。