Objective To study the clinical features of HPV58-positive cervical cancer. Methods A retrospective analysis of 347 patients with HPV58- or HPV16 positive cervical cancer from the Department of Gynecology Tumor of Guangxi Medical University Affiliated Cancer Hospital was performed. Molecular hybridization was used to detect HPV genotypes. The clinical features, including age, pathology, and invasion, were compared between the HPV58 positive and HPV16 positive cervical cancer groups. Results A total of 347 patients were eligible for this study, and the proportion of patients who were with poorly differentiated cancer ( P = 0.015) was significantly higher in the HPV58 positive group. HPV58 positivity was an independent risk factor for poorly differentiated cancer [HR 2.156, 95% confidence interval: 1.167–3.984, P = 0.014]. The percentage of uterus corps invasion is significantly lower in HPV58 ( p = 0.041), but HPV58 positivity is the independent risk factor for uterus corps invasion [HR = 3.985, 95% confidence interval: 1.066–14.893, P = 0.040]. The overall survival of HPV58-positive cervical cancer patients with uterine corpus invasion was significantly lower ( P = 0.000). The age of patients in the HPV58-positive cervical cancer at advanced stage was significantly older ( P = 0.045). Conclusions HPV58-positive cervical cancer patients are at higher risk of poorly differentiated cancer and uterus corps invasion. The patients with HPV58 positive cervical cancer with uterus corps invasion may result a worse prognosis.

中文翻译：

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HPV58阳性宫颈癌临床分析

目的研究HPV58阳性宫颈癌的临床特点。方法对广西医科大学附属肿瘤医院妇科肿瘤347例HPV58或HPV16阳性宫颈癌患者进行回顾性分析。分子杂交用于检测HPV基因型。比较HPV58阳性和HPV16阳性宫颈癌组的临床特征，包括年龄、病理和侵袭。结果共有347例患者符合本研究的条件，HPV58阳性组低分化癌患者比例（P=0.015）显着升高。HPV58 阳性是低分化癌症的独立危险因素 [HR 2.156, 95% 置信区间：1.167–3.984, P = 0.014]。HPV58的子宫肌层浸润百分比显着降低（p = 0.041），但HPV58阳性是子宫肌层浸润的独立危险因素[HR = 3.985，95%置信区间：1.066-14.893，P = 0.040]。HPV58阳性宫颈癌患者子宫体侵犯的总生存期显着降低（P=0.000）。HPV58阳性的晚期宫颈癌患者年龄明显偏大（P=0.045）。结论 HPV58阳性宫颈癌患者发生低分化癌和子宫肌层浸润的风险较高。HPV58阳性宫颈癌伴子宫肌层浸润的患者预后可能较差。95% 置信区间：1.066–14.893，P = 0.040]。HPV58阳性宫颈癌患者子宫体侵犯的总生存期显着降低（P=0.000）。HPV58阳性的晚期宫颈癌患者年龄明显偏大（P=0.045）。结论 HPV58阳性宫颈癌患者发生低分化癌和子宫肌层浸润的风险较高。HPV58阳性宫颈癌伴子宫肌层浸润的患者预后可能较差。95% 置信区间：1.066–14.893，P = 0.040]。HPV58阳性宫颈癌患者子宫体侵犯的总生存期显着降低（P=0.000）。HPV58阳性的晚期宫颈癌患者年龄明显偏大（P=0.045）。结论 HPV58阳性宫颈癌患者发生低分化癌和子宫肌层浸润的风险较高。HPV58阳性宫颈癌伴子宫肌层浸润的患者预后可能较差。结论 HPV58阳性宫颈癌患者发生低分化癌和子宫肌层浸润的风险较高。HPV58阳性宫颈癌伴子宫肌层浸润的患者预后可能较差。结论 HPV58阳性宫颈癌患者发生低分化癌和子宫肌层浸润的风险较高。HPV58阳性宫颈癌伴子宫肌层浸润的患者预后可能较差。