Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy.,Chemical Communications

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Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-06-05 , DOI: 10.1039/d0cc03589k
Longbing Ling ₁ , Haizhou Yu , Muhammad Ismail , Yanping Zhu , Yuan Du , Junhui Qi

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An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy.

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