TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.

中文翻译：

---

DNMT3A和TET2突变以相反的方式重塑造血功能。

尽管TET2和DNMT3A编码蛋白具有拮抗的生化功能，但它们在血液癌中的长期结果相似。一项新研究强调了TET2和DNMT3A突变在塑造造血祖细胞的早期红系或髓系偏向方面的相反作用。