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Impact of dietary propionate on fructose-induced changes in lipid metabolism, gut microbiota and short-chain fatty acids in mice
International Journal of Food Sciences and Nutrition ( IF 3.5 ) Pub Date : 2020-06-04 , DOI: 10.1080/09637486.2020.1773415
Christine Brütting 1 , Milena Lara Bisch 1 , Corinna Brandsch 1 , Frank Hirche 1 , Gabriele I Stangl 1
Affiliation  

Abstract

Propionate has antimicrobial activity and is suggested to influence lipid metabolism. Here, we investigated the effect of propionate on lipid metabolism and the gut microbiome in fructose-fed mice as a model of diet-induced steatosis and gut dysbiosis. Therefore, 48 male wild-type mice were fed isoenergetic diets with either 0% fructose (F–) or 40% fructose (F+) that contained 0% propionate (P–) or 1% propionate (P+) for 7 weeks. Mice that received the F+ diets developed fatty livers, had fewer small intestinal proteobacteria and colonic actinobacteria and were characterised by changes in bacterial genera (e.g., Allobaculum, Lachnospiraceae, and Escherichia). Interestingly, mice fed the F+ diets had higher levels of propionate and butyrate in the circulation than mice fed the F– diets (p < 0.05). Treatment with propionate influenced neither hepatic or plasma lipids nor levels of circulating SCFAs. With the exception of Verrucomicrobia, other bacterial phyla were not affected by propionate.



中文翻译:

膳食丙酸盐对果糖诱导的小鼠脂质代谢、肠道微生物群和短链脂肪酸变化的影响

摘要

丙酸盐具有抗菌活性,并被建议影响脂质代谢。在这里,我们研究了丙酸盐对果糖喂养小鼠脂质代谢和肠道微生物组的影响,作为饮食诱导的脂肪变性和肠道菌群失调的模型。因此,48 只雄性野生型小鼠被喂食含有 0% 果糖 (F-) 或 40% 果糖 (F+) 且含有 0% 丙酸盐 (P-) 或 1% 丙酸盐 (P+) 的等能饮食 7 周。接受 F+ 饮食的小鼠出现脂肪肝,小肠变形菌和结肠放线菌较少,并以细菌属(如异芽孢杆菌毛螺菌科和埃希氏菌)的变化为特征。)。有趣的是,喂食 F+ 饮食的小鼠在循环中的丙酸盐和丁酸盐水平高于喂食 F- 饮食的小鼠(p  < 0.05)。丙酸盐治疗既不影响肝脏或血浆脂质,也不影响循环 SCFA 的水平。除疣微菌外,其他细菌门不受丙酸盐影响。

更新日期:2020-06-04
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