Primary Objective

Traumatic brain injury (TBI) is associated with higher incidence of neurodegenerative disease and the effects of aging appear more pronounced after TBI. This paper examines the potential interaction of aging, TBI, and change in male testosterone production.

Methods and Procedures

An abbreviated review of literature documenting hypogonadism after TBI is provided. Potential mechanisms of endocrine dysgrasia associated with aging are reviewed as they relate and interact with endocrine change after TBI in males. These factors align to suggest the need for development of surveillance guidelines for male individuals living with TBI.

Outcomes and Results

The neuroprotectant, neuroactivation, growth, and cell therapy characteristics of testosterone in the central nervous system are considerable. Age-related decrements in testosterone production may be accelerated after TBI.

Conclusions

Testosterone deficiency in male individuals after TBI can be present after TBI or can develop during aging. Age-related decreases in testosterone production after TBI may act to amplify endocrine dysfunction after TBI. Ongoing clinical surveillance for testosterone deficiency associated with both TBI and aging may be reasonable.

中文翻译：

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获得性脑损伤后睾丸激素，性类固醇和神经退行性疾病的衰老：评论。

主要目标

颅脑外伤（TBI）与神经退行性疾病的发生率较高相关，并且在TBI后，衰老的影响更为明显。本文研究了衰老，TBI和男性睾丸激素生产变化之间的潜在相互作用。

方法与程序

提供了简短的文献综述，记载了TBI后性腺功能减退。综述了与衰老相关的内分泌功能异常的潜在机制，因为它们与男性TBI后内分泌变化相关并相互作用。这些因素相吻合，表明有必要为TBI男性患者制定监测指南。

结果与结果

中枢神经系统中睾丸激素的神经保护，神经激活，生长和细胞治疗特性十分重要。TBI后，与年龄有关的睾丸激素产量下降可能会加速。

结论

TBI后男性的睾丸激素缺乏症可能在TBI之后出现，也可能在衰老过程中发展。TBI后与年龄相关的睾丸激素生成减少可能会加剧TBI后的内分泌功能障碍。持续进行与TBI和衰老相关的睾丸激素缺乏症的临床监测可能是合理的。