Abstract This article describes synthesis and characterization of three oxidovanadium(IV) complexes using BPA (BPA = 2,2’-bis(pyridylmethyl)amine), 2,2-bipyridyl and 1,10-phenanthroline. These complexes were characterized by elemental analysis, spectroscopic (UV-vis, IR and EPR) and electrochemical methods. Room temperature magnetic susceptibility data show the paramagnetic nature of the complexes. Complexes were also characterized by electron paramagnetic resonance (EPR) spectral techniques. The optimized molecular structures show the presence of N3O3/N5O donor atoms in six-coordinate geometry. These complexes were evaluated and compared using thermogravimetric analysis and powder X-ray diffraction techniques. The species exhibit only one-electron reduction wave at a more negative potential. The catalytic activity of these complexes was also explored to mimic α-glucosidase and α-amylase activity. Moderate α-glucosidase and α-amylase inhibitors are shown by all complexes. These observations are expected to expand the possibility of designing new oxidovanadium(IV) complexes with significant anti-diabetic properties. Graphical Abstract

中文翻译：

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包含 2,2'-双（吡啶基甲基）胺和多吡啶基配体的氧化钒 (IV) 配合物的实验、量子计算研究和体外抗糖尿病活性

摘要 本文介绍了使用 BPA（BPA = 2,2'-双（吡啶基甲基）胺）、2,2-联吡啶和 1,10-菲咯啉合成和表征三种氧化钒 (IV) 配合物。这些配合物通过元素分析、光谱（UV-vis、IR 和 EPR）和电化学方法进行表征。室温磁化率数据显示配合物的顺磁性。配合物的特征还在于电子顺磁共振 (EPR) 光谱技术。优化的分子结构显示在六坐标几何中存在 N3O3/N5O 供体原子。使用热重分析和粉末 X 射线衍射技术对这些配合物进行了评估和比较。该物种在更负的电位下仅表现出单电子还原波。还探索了这些复合物的催化活性以模拟 α-葡萄糖苷酶和 α-淀粉酶活性。所有复合物均显示中度α-葡萄糖苷酶和α-淀粉酶抑制剂。这些观察结果有望扩大设计具有显着抗糖尿病特性的新型氧化钒 (IV) 配合物的可能性。图形概要