Prenatal mercury (Hg) exposure was determined in a sub-cohort of the Caribbean Consortium for Environmental and Occupational Health’s environmental epidemiologic prospective cohort study of pregnant women living in Suriname’s interior. The associations between Hg exposure, low birth weight (LBW, <2500 g) and preterm birth (PTB, <37 weeks) were explored. Correlation analysis, Fisher’s exact test and logistic regression analyses were conducted to evaluate the associations between maternal hair Hg levels and birth weight, LBW and PTB, and between potential confounders, LBW and PTB, respectively. Among 204 singleton births were 198 live births, five stillbirths and one miscarriage. The mean participant age was 26 years; 15.7% of participants had PTBs and 8.1% delivered a child with a LBW. The median hair Hg level was 3.48 μg/g hair. Low hair Hg exposure, based on lowest tertile < 2.34 μg/g, was associated with LBW (OR = 7.2; 95% CI 1.5–35.6; p = 0.015); this association was independent of maternal age, ethnic background, household income and village location, and no correlation was found between hair Hg and PTB. Young maternal age was associated with PTB (RR = 5.09, 95% CI: 1.92–13.85; p = 0.0004) while maternal age was not associated with hair Hg or LBW. The impact of prenatal Hg exposure on pediatric neurodevelopment is currently being evaluated in the infant sub-cohort.

中文翻译：

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苏里南内陆孕妇的产前汞暴露及其对出生结果的影响。

产前汞 (Hg) 暴露是在加勒比环境与职业健康联盟的一个子队列中确定的，该队列对居住在苏里南内陆的孕妇进行了环境流行病学前瞻性队列研究。探讨了汞暴露、低出生体重（LBW，<2500 g）和早产（PTB，<37 周）之间的关联。相关性分析、Fisher 精确检验和逻辑回归分析分别用于评估母亲头发 Hg 水平与出生体重、LBW 和 PTB 之间的关联，以及潜在混杂因素 LBW 和 PTB 之间的关联。在 204 例单胎分娩中，活产 198 例，死产 5 例，流产 1 例。参与者的平均年龄为 26 岁；15.7% 的参与者患有 PTB，8.1% 的孩子生下了 LBW。头发汞含量中位数为 3.48 微克/克头发。p = 0.015); 这种关联与母亲年龄、种族背景、家庭收入和村庄位置无关，并且在头发 Hg 和 PTB 之间没有发现相关性。年轻的母亲年龄与 PTB 相关（RR = 5.09，95% CI：1.92–13.85；p = 0.0004），而母亲年龄与头发 Hg 或 LBW 无关。目前正在婴儿亚组中评估产前汞暴露对小儿神经发育的影响。