Scalable Formation of Concentrated Monodisperse Lignin Nanoparticles by Recirculation‐Enhanced Flash Nanoprecipitation,Particle & Particle Systems Characterization

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Scalable Formation of Concentrated Monodisperse Lignin Nanoparticles by Recirculation‐Enhanced Flash Nanoprecipitation
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-06-05 , DOI: 10.1002/ppsc.202000122
Cathryn G. Conner ₁ , Anka N. Veleva ₂ , Vesselin N. Paunov ₃ , Simeon D. Stoyanov ₄ , Orlin D. Velev ₁

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A highly controllable and scalable process for fabrication of large amounts of concentrated lignin nanoparticles (LNPs) is reported. These lignin core nanoparticles are formed through flash nanoprecipitation, however, scaling up of the fabrication process requires fundamental understanding of their operational formation mechanism and surface properties. It is shown how a semicontinuous synthesis system with a recirculation loop makes it possible to produce flash precipitated lignin nanoparticles in large amounts for practical applications. The roles of the process parameters, including flow rates and lignin concentration, are investigated and analyzed. The results indicate that the LNPs are formed by a process of continuous burst nucleation at the point of mixing without diffusive growth, which yields nanoparticles of highly uniform size following a modified LaMer nucleation and growth mechanism. This mechanism makes possible facile process control and scale-up. Effective control of the resulting nanoparticle size is achieved through the initial concentration of lignin in the injected solution. The impressive capability to produce suspensions of any predesigned multimodal distribution is demonstrated. The resulting nanofabrication technique can produce large volumes of concentrated LNP suspensions of high stability and tightly controlled size distributions for biological or agricultural applications.

中文翻译：

通过再循环增强的闪蒸纳米沉淀可大规模形成浓缩的单分散木质素纳米颗粒

报道了一种用于制造大量浓缩木质素纳米粒子 (LNP) 的高度可控和可扩展的过程。这些木质素核心纳米粒子是通过快速纳米沉淀形成的，然而，扩大制造过程需要对其操作形成机制和表面特性有基本的了解。展示了具有再循环回路的半连续合成系统如何能够为实际应用大量生产快速沉淀的木质素纳米颗粒。研究和分析了工艺参数的作用，包括流速和木质素浓度。结果表明，LNPs 是通过在混合点连续爆发成核的过程形成的，没有扩散生长，根据改良的 LaMer 成核和生长机制，产生高度均匀的纳米颗粒。这种机制使得容易的过程控制和放大成为可能。通过注射溶液中木质素的初始浓度实现对所得纳米颗粒尺寸的有效控制。展示了生产任何预先设计的多峰分布的悬浮液的令人印象深刻的能力。由此产生的纳米制造技术可以为生物或农业应用生产大量高稳定性和严格控制的尺寸分布的浓缩 LNP 悬浮液。通过注射溶液中木质素的初始浓度实现对所得纳米颗粒尺寸的有效控制。展示了生产任何预先设计的多峰分布的悬浮液的令人印象深刻的能力。由此产生的纳米制造技术可以为生物或农业应用生产大量高稳定性和严格控制的尺寸分布的浓缩 LNP 悬浮液。通过注射溶液中木质素的初始浓度实现对所得纳米颗粒尺寸的有效控制。展示了生产任何预先设计的多峰分布的悬浮液的令人印象深刻的能力。由此产生的纳米制造技术可以为生物或农业应用生产大量高稳定性和严格控制的尺寸分布的浓缩 LNP 悬浮液。

更新日期：2020-06-05

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