Porous Magnetic Nanoparticles‐Based Electrochemical Biosensor for Determination of Mercury in the Aquatic Environment,Particle & Particle Systems Characterization

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Porous Magnetic Nanoparticles‐Based Electrochemical Biosensor for Determination of Mercury in the Aquatic Environment
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-06-05 , DOI: 10.1002/ppsc.202000074
Jinjiang Cui _{1,

2} , Ningning Dong ₁ , Mingyuan Wang ₃ , Yu Jiang ₄ , Peng Miao ₁

Affiliation

Fabrication of sensitive and convenient methods for the detection of heavy metal ions is an important task due to their high toxicity to environment and human health. Divalent mercury ions (Hg²⁺) are a kind of significant public health hazard, which generate harmful toxic effects. In this work, a novel self‐powered biosensor for the quantification of Hg²⁺ in aqueous solutions is developed. Porous magnetic nanoparticles are synthesized to load electrochemical species and a Hg²⁺ responsive single‐stranded DNA probe is used to seal them. After specific interaction with target ions, the DNA probe forms a rigid duplex, which can no longer block the pores of the magnetic nanoparticles. The leakage of electrochemical species can then increase the electrochemical response, which is used to indicate the initial concentration of Hg²⁺. This method shows high sensitivity and selectivity, and can be applied in real water samples with excellent recoveries. Therefore, a novel approach is provided for ultrasensitive and reliable detection of Hg²⁺ in practical applications.

中文翻译：

基于多孔磁性纳米粒子的电化学生物传感器，用于测定水生环境中的汞

由于重金属离子对环境和人体健康具有高毒性，因此，制造灵敏且方便的检测重金属离子的方法是一项重要任务。二价汞离子（Hg ²⁺）是一种严重的公共健康危害，会产生有害的毒性作用。在这项工作中，开发了一种新型的自供电生物传感器，用于定量水溶液中的Hg ²⁺。合成多孔磁性纳米粒子以加载电化学物质和Hg ²⁺反应灵敏的单链DNA探针用于密封它们。与目标离子发生特异性相互作用后，DNA探针形成一个刚性双链体，该双链体不再能够阻塞磁性纳米颗粒的孔。然后，电化学物质的泄漏会增加电化学反应，该反应用于指示Hg ²⁺的初始浓度。该方法具有很高的灵敏度和选择性，可用于回收率极高的实际水样中。因此，为实际应用中的Hg ^2+的超灵敏可靠检测提供了一种新颖的方法。

更新日期：2020-06-05

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