The deposition of amyloid‐β (Aβ) peptides in the form of extracellular plaques in the brain represents one of the classical hallmarks of Alzheimer’s disease (AD). In addition to ‘full‐length’ Aβ starting with aspartic acid (Asp‐1), considerable amounts of various shorter, N‐terminally truncated Aβ peptides have been identified by mass spectrometry in autopsy samples from individuals with AD.

中文翻译：

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阿尔茨海默病中实质和血管淀粉样蛋白 β 沉积物的 N 端异质性

淀粉样蛋白 β (Aβ) 肽在大脑中以细胞外斑块的形式沉积是阿尔茨海默病 (AD) 的经典标志之一。除了以天冬氨酸 (Asp-1) 开始的“全长”Aβ 外，还通过质谱法在 AD 患者的尸检样本中鉴定了大量各种较短的、N 端截短的 Aβ 肽。