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Poly-L-lactide scaffolds with super pores obtained by freeze-extraction method.
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2020-06-05 , DOI: 10.1002/jbm.b.34642
Monika Budnicka 1 , Dorota Kołbuk 2 , Paweł Ruśkowski 1 , Agnieszka Gadomska-Gajadhur 1
Affiliation  

A nonplanar polylactide scaffold to be used in tissue engineering was obtained by freeze‐extraction method. Properties of the scaffold were modified by adding Eudragit® E100. The impact of the modification on morphology, porosity and pore size, mass absorbability, mechanical properties was determined. Scanning electron microscopy (SEM), hydrostatic weighing test, static compression test was used to this end. The chemical composition of the scaffold was defined based on infrared spectroscopy (FTIR) and energy‐dispersive X‐ray spectroscopy (EDX). Biocompatibility was confirmed by quantitative tests and microscopic observation. The obtained results show that the obtained scaffolds may be applied as a carrier of hydrophilic cellular growth factors for more efficient tissue regeneration.

中文翻译:

通过冷冻提取方法获得的具有超孔的聚-L-丙交酯支架。

通过冷冻提取方法获得了用于组织工程的非平面聚乳酸支架。通过添加 Eudragit® E100 修改了支架的特性。确定了改性对形态、孔隙率和孔径、质量吸收性、机械性能的影响。为此使用了扫描电子显微镜(SEM)、静水压称重试验、静态压缩试验。基于红外光谱(FTIR)和能量色散X射线光谱(EDX)定义支架的化学成分。通过定量测试和显微镜观察证实了生物相容性。所得结果表明,所获得的支架可用作亲水性细胞生长因子的载体,以实现更有效的组织再生。
更新日期:2020-06-05
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