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Recent Progress in the Consecutive Double Heck Reaction
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-06-04 , DOI: 10.1002/ajoc.202000230
Baihang Ju 1 , Wangqing Kong 1
Affiliation  

Group website: http://wqkong.whu.edu.cnAlthough the Heck reaction has been discovered for more than 50 years, there remains significant opportunities for chemists to make new discoveries. The traditional Heck reaction is mainly limited to the arylation of alkenes, but the efficient construction of diverse polycyclic scaffolds bearing an alkenyl functional group in one‐pot operation by consecutive double Heck cyclization has been scarcely investigated. We therefore summarise the recent progress in Pd‐ and Ni‐catalyzed consecutive double Heck cyclization and highlight the enantioselective transformations and their applications in the total synthesis of natural products with congested quaternary carbon stereocenters.

中文翻译:

连续性双Heck反应的最新进展

该小组的网站:http://wqkong.whu.edu.cn尽管发现了Heck反应已有50多年的历史,但化学家仍有大量机会做出新发现。传统的Heck反应主要限于烯烃的芳基化反应,但几乎没有研究过通过连续双Heck环化反应在单锅操作中有效地构建带有烯基官能团的多种多环骨架的方法。因此,我们总结了Pd和Ni催化的连续双Heck环化反应的最新进展,并重点介绍了对映选择性转化及其在具有拥挤的季碳立体中心的天然产物的全合成中的应用。
更新日期:2020-08-08
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