Bone marrow (BM) is a preferential metastatic site for solid cancers, contributing to higher morbidity and mortality among millions of oncologic patients worldwide. There are no current efficient therapies to minimize this health burden. Microfluidic based in vitro models emerge as powerful alternatives to animal testing, as well as promising tools for the development of personalized medicine solutions. The complexity associated with the BM metastatic niche originated a wide variety of microfluidic platforms designed to mimic this microenvironment. This review gathers the essential parameters to design an accurate in vitro microfluidic device, based on a comparative analysis of existing models created to address the different steps of the metastatic cascade.

骨髓 (BM) 是实体癌的优先转移部位，导致全球数百万肿瘤患者的发病率和死亡率更高。目前没有有效的疗法来最小化这种健康负担。基于微流体的体外模型成为动物试验的有力替代品，以及用于开发个性化医疗解决方案的有前途的工具。与 BM 转移性生态位相关的复杂性起源于各种旨在模拟这种微环境的微流体平台。本综述收集了设计精确体外微流体装置的基本参数，基于对现有模型的比较分析，以解决转移级联的不同步骤。