We compared the exercise ventilatory response (slope of the ventilation, V̇_E and carbon dioxide production, V̇CO₂ relationship) in boys and girls with and without obesity. 46 children with obesity (BMI percentile: 97.7 ± 1.4) and 27 children without obesity (BMI percentile: 55.1 ± 22.2) were included and divided into groups by sex (with obesity: 17 girls and 29 boys; without obesity: 13 girls and 14 boys). A 6 min constant load cycling test at 45 % of peak work rate was performed. The V̇_E/V̇CO₂ slope was similar (p = 0.67) between children with (32.7 ± 4.3) and without (32.2 ± 6.1) obesity; however, it was higher (p = 0.02) in girls (35.4 ± 5.6) than boys (32.6 ± 4.9). We also examined a corrected V̇_E/V̇CO₂ slope for the effects of mechanical dead space (V_DM), by subtracting V̇_DM from V̇_E (V̇_Ecorr/V̇CO₂ slope). The V̇_Ecorr/V̇CO₂ slope remained similar (p = 0.37) between children with (26.8 ± 3.2) and without obesity (26.1 ± 3.1); however, no sex differences were observed (p = 0.13). Therefore, V_DM should be accounted for before evaluating the V̇_E/V̇CO₂ slope, particularly when making between-sex comparisons.

我们比较了肥胖和非肥胖男孩和女孩的运动通气反应（通气斜率、V̇ _E和二氧化碳产生、V̇CO ₂关系）。46名肥胖儿童（BMI百分位：97.7±1.4）和27名非肥胖儿童（BMI百分位：55.1±22.2）被纳入并按性别分组（肥胖：17女孩和29男孩；非肥胖：13女孩和14男孩们）。以 45% 的峰值工作速率进行了 6 分钟的恒定负载循环测试。V̇ _E /V̇CO ₂斜率在有 (32.7 ± 4.3) 和没有 (32.2 ± 6.1) 肥胖的儿童之间相似（p = 0.67）；然而，女孩 (35.4 ± 5.6) 高于男孩 (32.6 ± 4.9) (p = 0.02)。我们还检查了修正后的 V̇ _E /V̇CO₂斜率的机械死区（V效果_DM），通过减去V̇ _DM从V _È（V_{自腐蚀电位}/ VCO ₂斜率）。在V_{自腐蚀电位}/ VCO ₂斜率保持类似的儿童之间（P = 0.37）与（26.8±3.2）和不肥胖（26.1±3.1）; 然而，没有观察到性别差异（p = 0.13）。因此，在评估 V̇ _E /V̇CO ₂斜率之前，应考虑V _DM，尤其是在进行性别比较时。