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The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating.
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2020-06-05 , DOI: 10.1016/j.nlm.2020.107266
Lingxuan Chen 1 , Kirstie A Cummings 1 , William Mau 1 , Yosif Zaki 1 , Zhe Dong 1 , Sima Rabinowitz 1 , Roger L Clem 1 , Tristan Shuman 1 , Denise J Cai 1
Affiliation  

Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.



中文翻译:

内在兴奋性在记忆进化中的作用:在记忆分配、巩固和更新中的意义。

记忆是一个动态过程,不断受到突触和内在神经机制的调节。虽然大量研究表明突触可塑性在学习和记忆的各种类型和阶段都很重要,但神经元内在兴奋性受到的关注相对较少,尤其是在记忆的动态特性方面。在这篇综述中,我们提供了证据证明内在兴奋性在内存分配、整合和更新中的重要性。我们还考虑了内在兴奋性和突触可塑性在塑造记忆中的复杂相互作用,支持记忆稳定性和灵活性。

更新日期:2020-06-23
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