The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.

中文翻译：

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MicroRNA在造血干细胞衰老中。

在HSCs中观察到的衰老的功能下降主要归因于调节静止，自我更新和分化的细胞内在因素。微小RNA（miRs）在HSC的调节中起着不可或缺的作用，并且已显示它还可以调节与特定细胞类型中的组织衰老相关的过程。在这里，我们讨论了miR在整个生命过程中对HSC自我更新和分化的调控中的作用及其对未来研究的影响。