3D in silico study of magnetic fluid hyperthermia of breast tumor using Fe3O4 magnetic nanoparticles,Journal of Thermal Biology

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3D in silico study of magnetic fluid hyperthermia of breast tumor using Fe3O4 magnetic nanoparticles
Journal of Thermal Biology ( IF 2.9 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.jtherbio.2020.102635
Muhammad Suleman ₁ , Samia Riaz ₂

Affiliation

Modeling and simulation of the temperature distribution, the mass concentration, and the heat transfer in the breast tissue are hot issues in magnetic fluid hyperthermia treatment of cancer. The breast tissue can be visualized as a porous matrix with saturated blood. In this paper, 3D in silico study of breast cancer hyperthermia using magnetic nanoparticles (MNPs) is conducted. The 3D FEM models are incorporated to investigate the infusion and backflow of nanofluid in the breast tumor, the diffusion of nanofluid, temperature distribution during the treatment, and prediction of the fraction of tumor necrosis while dealing with the thermal therapy. All the hyperthermia procedures are simulated and analyzed on COMSOL Multiphysics. The sensitivity of frequency and amplitude of the applied magnetic field (AMF) is investigated on the heating effect of the tumor. The mesh dependent solution of Penne's bioheat model is also analyzed. The simulated results demonstrate successful breast cancer treatment using MNPs with minimum side effects. Validation of current simulations results with experimental studies existing in literature advocates the success of our therapy. The increase in the amplitude and frequency of the AMF increases of the temperature in the tumor. The variation of mesh from coarser to finer increased the temperature through small fractions. We have also simulated the magnetic induction problem where the magnetic field is generated by current-carrying coil conductors induce heat in nearby breast tumors due to excitation of MNPs by magnetic flux. This research will aid treatment protocols and real-time clinical breast cancer treatments.

中文翻译：

使用 Fe3O4 磁性纳米颗粒对乳腺肿瘤进行磁流体热疗的 3D 计算机模拟研究

乳腺组织中温度分布、质量浓度和传热的建模和仿真是磁流体热疗治疗癌症的热点问题。乳房组织可以被视为具有饱和血液的多孔基质。在本文中，使用磁性纳米粒子 (MNP) 对乳腺癌热疗进行了 3D 计算机模拟研究。结合 3D FEM 模型来研究纳米流体在乳腺肿瘤中的输注和回流、纳米流体的扩散、治疗过程中的温度分布以及在处理热疗时预测肿瘤坏死的比例。所有的热疗程序都在 COMSOL Multiphysics 上进行了模拟和分析。研究了外加磁场 (AMF) 的频率和幅度对肿瘤加热效应的敏感性。还分析了 Penne 生物热模型的网格相关解。模拟结果表明使用 MNP 成功治疗乳腺癌，副作用最小。通过文献中现有的实验研究验证当前的模拟结果表明我们的治疗取得了成功。AMF 振幅和频率的增加会增加肿瘤中的温度。网格从粗到细的变化通过小部分提高了温度。我们还模拟了磁感应问题，其中，由于磁通量对 MNP 的激发，载流线圈导体产生的磁场在附近的乳腺肿瘤中感应热量。

更新日期：2020-07-01

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