Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ability to synthesize diverse classes of highly active biogenic metabolites. Here, for the first time, we reviewed all possible algal metabolites with broad spectra antibacterial activity against pathogenic bacteria, including antibiotic-resistant strains, and categorized different metabolites of both freshwater and marine algae, linking them on the basis of their target sites and mechanistic actions along with their probable nanoconjugates. Algae can be considered a boon for novel drug discovery in the era of antibiotic resistance, as various algal primary and secondary metabolites possess potential antibacterial properties. The diversity of these metabolites from indigenous sources provides a promising gateway enabling researchers and pharmaceutical companies to develop novel nontoxic, cost-effective and highly efficient antibacterial medicines.

抗生素耐药性正在以难以应对的速度上升。规避此问题需要快速有效的替代常规抗生素。藻类生活在广泛的生态系统中，这有助于藻类合成各种类别的高活性生物代谢产物。在这里，我们首次审查了所有可能的对病原菌具有广谱抗菌活性的藻类代谢物，包括抗药性菌株，并对淡水和海藻的不同代谢物进行了分类，并根据它们的目标位点和机理将它们联系起来。及其可能的纳米共轭物。在抗药性时代，藻类可被视为发现新药的福音，因为各种藻类的主要和次要代谢物都具有潜在的抗菌特性。这些代谢产物来自本地的多样性为研究人员和制药公司开发新的无毒，经济高效的高效抗菌药物提供了一个有希望的途径。