Recent research progress on the “second generation” type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R₁–C–R₂ scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for future drug development.

中文翻译：

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通过非常规的III型聚酮化合物合酶生物合成具有重要医学意义的植物代谢物。

总结了“第二代” III型聚酮化合物合酶的最新研究进展。这类酶催化不同寻常的CoA硫酯缩合化学反应，以生成具有医学重要性的植物次生代谢产物的各种核心结构，包括烷基喹诺酮的R ₁ -C–R ₂支架，姜黄素以及8-氮杂双环[3.2.1]。 ]辛烷环的托烷生物碱。这种令人着迷的酶超家族的发现为酶反应的操纵提供了极好的机会，以扩大天然和非天然分子的供应，以用于未来的药物开发。