Microbial interactions shape the structure and function of microbial communities; microbial co-occurrence networks in specific environments have been widely developed to explore these complex systems, but their interconnection pattern across microbiomes in various environments at the global scale remains unexplored. Here, we have inferred an Earth microbial co-occurrence network from a communal catalog with 23,595 samples and 12,646 exact sequence variants from 14 environments in the Earth Microbiome Project dataset. This non-random scale-free Earth microbial co-occurrence network consisted of 8 taxonomy distinct modules linked with different environments, which featured environment specific microbial co-occurrence relationships. Different topological features of subnetworks inferred from datasets trimmed into uniform size indicate distinct co-occurrence patterns in the microbiomes of various environments. The high number of specialist edges highlights that environmental specific co-occurrence relationships are essential features across microbiomes. The microbiomes of various environments were clustered into two groups, which were mainly bridged by the microbiomes of plant and animal surface. Acidobacteria Gp2 and Nisaea were identified as hubs in most of subnetworks. Negative edges proportions ranged from 1.9% in the soil subnetwork to 48.9% the non-saline surface subnetwork, suggesting various environments experience distinct intensities of competition or niche differentiation. This investigation highlights the interconnection patterns across microbiomes in various environments and emphasizes the importance of understanding co-occurrence feature of microbiomes from a network perspective.

中文翻译：

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地球微生物共生网络揭示了跨微生物群落的互连模式。

微生物相互作用决定了微生物群落的结构和功能。特定环境中的微生物共生网络已得到广泛开发，以探索这些复杂的系统，但在全球范围内，它们在各种环境中的微生物群落之间的互连模式尚未得到探索。在这里，我们从一个公共目录中推断出了一个地球微生物共现网络，该网络包含来自地球微生物组项目数据集中14个环境的23595个样本和12646个确切的序列变体。这个非随机，无标度的地球微生物共生网络由与不同环境链接的8个分类学不同模块组成，这些模块具有特定于环境的微生物共生关系。从修剪成统一大小的数据集推断出的子网络的不同拓扑特征表明，在各种环境的微生物群落中不同的共生模式。专家优势的高数量表明，特定于环境的共现关系是整个微生物群落的基本特征。各种环境的微生物群被分为两组，主要是由植物和动物表面的微生物群桥接。在大多数子网络中，酸性细菌Gp2和Nisaea被确定为中心。负边缘比例范围从土壤子网中的1.9％到非盐表面子网中的48.9％，这表明各种环境经历的竞争或生态位分化强度不同。