Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces.,Lab on a Chip

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Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-06-04 , DOI: 10.1039/d0lc00477d
Wenguang Yang ₁ , Lujing Sun , Shuxiang Cai , Yibao Chen , Wenfeng Liang , Peilin Zhou , Haibo Yu , Yuechao Wang , Lianqing Liu

Affiliation

Cell adhesion plays an important role in cell communication, organ formation and tissue maintenance. Spatial microstructure patterning has the capability to regulate cell functions such as cell adhesion and cell proliferation as well as cellular mechanical properties. In this study, we present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Micro-hump structures were rapidly fabricated by E-jet printing and arbitrary cell patterns can be achieved by selective cell adhesion induced by this surface topography. Furthermore, cellular mechanical properties were regulated by changing the density of microstructures. The technique we proposed could dynamically direct cell organization in a controlled manner, providing help for exploring the fundamental mechanism of cell adhesion and sensing.

中文翻译：

通过微驼峰结构图案化的细胞粘附界面动态指导细胞组织。

细胞粘附在细胞通讯，器官形成和组织维持中起重要作用。空间微结构构图具有调节细胞功能的能力，例如细胞粘附和细胞增殖以及细胞机械性能。在这项研究中，我们提出了一种简单的方法来制造基于电动力喷射（E-jet）印刷的微驼峰图案化界面，以控制和指导细胞组织。微隆起结构通过E-jet印刷快速制造，通过这种表面形貌诱导的选择性细胞粘附可以实现任意细胞图案。此外，通过改变微结构的密度来调节细胞的机械性能。我们提出的技术可以以受控方式动态指导细胞组织，

更新日期：2020-07-14

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