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Metamorphic Proteins in Light of Anfinsen's Dogma.
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2020-06-04 , DOI: 10.1021/acs.jpclett.0c01414
Jorge A Vila 1
Affiliation  

It is a common belief that metamorphic proteins challenge Anfinsen’s thermodynamic hypothesis (or dogma). Here we argue against this view and aim to show that metamorphic proteins not only fulfill Anfinsen’s dogma but also exhibit marginal stability comparable to that seen on biomolecules and macromolecular complexes. This work contributes to our general understanding of protein classification and may spur significant progress in our effort to analyze protein evolvability.

中文翻译:

根据安芬森教条的变形蛋白。

人们普遍认为,变形蛋白会挑战安芬森的热力学假设(或教条)。在这里,我们反对这种观点,旨在表明变质蛋白不仅能满足安芬森教条,而且还具有与生物分子和大分子复合物相当的边际稳定性。这项工作有助于我们对蛋白质分类的一般理解,并可能促进我们分析蛋白质进化能力的重大进展。
更新日期:2020-07-02
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