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Red Blood Cells and Lipoproteins: Important Reservoirs and Transporters of Polyphenols and Their Metabolites.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-06-04 , DOI: 10.1021/acs.jafc.0c02601 Salwa M Harbi 1 , Rania A Hussien 1 , Intesar Hawasawi 1 , Ibtehaj Alshdoukhi 1 , Vikram Chopra 1 , Amal N Alanazi 1 , William Butler 1 , Rakia Koroma 1 , Colin Peters 1 , Deanne D Garver 2 , Joe A Vinson
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-06-04 , DOI: 10.1021/acs.jafc.0c02601 Salwa M Harbi 1 , Rania A Hussien 1 , Intesar Hawasawi 1 , Ibtehaj Alshdoukhi 1 , Vikram Chopra 1 , Amal N Alanazi 1 , William Butler 1 , Rakia Koroma 1 , Colin Peters 1 , Deanne D Garver 2 , Joe A Vinson
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Dietary polyphenols are protective for chronic diseases. Their blood transport has not been well investigated. This work examines multiple classes of polyphenols and their interactions with albumin, lipoproteins, and red blood cell (RBC) compartments using four models and determines the % polyphenol in each compartment studied. The RBC alone model showed a dose–response polyphenol association with RBCs. A blood model with flavanones determined the % polyphenol that was inside RBCs and bound to the surface using a new albumin washing procedure. It was shown that RBCs can methylate flavanones. The whole blood model separated the polyphenol into four compartments with the aid of affinity chromatography. More polyphenols were found with albumin and lipoproteins (high-density lipoproteins and low-density lipoproteins) than with RBCs. In the plasma model, the polyphenols associated almost equally between lipoproteins and albumin. RBCs and lipoproteins are shown to be important reservoirs and transporters of polyphenols in blood.
中文翻译：
红细胞和脂蛋白：多酚及其代谢物的重要储库和转运蛋白。
饮食中的多酚对慢性病具有保护作用。他们的血液运输尚未得到充分研究。这项工作使用四个模型检查了多类多酚及其与白蛋白，脂蛋白和红细胞（RBC）隔室的相互作用，并确定了每个研究隔室中的多酚％。仅RBC模型显示出与RBC的剂量反应多酚缔合。含有黄烷酮的血液模型使用新的白蛋白洗涤程序确定了RBC内部并结合至表面的多酚％。结果表明，红细胞可以甲基化黄烷酮。全血模型借助亲和色谱将多酚分为四个部分。与白蛋白和脂蛋白（高密度脂蛋白和低密度脂蛋白）相比，发现多酚多于RBC。在血浆模型中，多酚在脂蛋白和白蛋白之间几乎相等地结合。RBC和脂蛋白被证明是血液中多酚的重要储存和转运蛋白。
更新日期：2020-07-01
中文翻译：
红细胞和脂蛋白：多酚及其代谢物的重要储库和转运蛋白。
饮食中的多酚对慢性病具有保护作用。他们的血液运输尚未得到充分研究。这项工作使用四个模型检查了多类多酚及其与白蛋白，脂蛋白和红细胞（RBC）隔室的相互作用，并确定了每个研究隔室中的多酚％。仅RBC模型显示出与RBC的剂量反应多酚缔合。含有黄烷酮的血液模型使用新的白蛋白洗涤程序确定了RBC内部并结合至表面的多酚％。结果表明，红细胞可以甲基化黄烷酮。全血模型借助亲和色谱将多酚分为四个部分。与白蛋白和脂蛋白（高密度脂蛋白和低密度脂蛋白）相比，发现多酚多于RBC。在血浆模型中，多酚在脂蛋白和白蛋白之间几乎相等地结合。RBC和脂蛋白被证明是血液中多酚的重要储存和转运蛋白。
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