Cells operate and react to environmental signals thanks to a complex network of protein–protein interactions (PPIs), the malfunction of which can severely disrupt cellular homeostasis. As a result, mapping and analyzing protein networks are key to advancing our understanding of biological processes and diseases. An invaluable part of these endeavors has been the house mouse (Mus musculus), the mammalian model organism par excellence, which has provided insights into human biology and disorders. The importance of investigating PPI networks in the context of mouse prompted us to develop the Mouse Integrated Protein–Protein Interaction rEference (MIPPIE). MIPPIE inherits a robust infrastructure from HIPPIE, its sister database of human PPIs, allowing for the assembly of reliable networks supported by different evidence sources and high-quality experimental techniques. MIPPIE networks can be further refined with tissue, directionality and effect information through a user-friendly web interface. Moreover, all MIPPIE data and meta-data can be accessed via a REST web service or downloaded as text files, thus facilitating the integration of mouse PPIs into follow-up bioinformatics pipelines.

中文翻译：

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MIPPIE：小鼠整合的蛋白质-蛋白质相互作用参考。

蛋白质-蛋白质相互作用（PPI）的复杂网络使细胞能够对环境信号进行操作并做出反应，其故障可能严重破坏细胞体内平衡。因此，对蛋白质网络进行定位和分析对于增进我们对生物学过程和疾病的理解至关重要。这些努力中，宝贵的一部分是家鼠（Mus musculus），这是卓越的哺乳动物模型生物，它为人类生物学和疾病提供了见识。在小鼠中研究PPI网络的重要性促使我们开发了小鼠整合蛋白-蛋白质相互作用参考（MIPPIE）。MIPPIE从HIPPIE（人类PPI的姊妹数据库）继承了强大的基础架构，允许组装由不同证据来源和高质量实验技术支持的可靠网络。MIPPIE网络可以通过用户友好的Web界面进一步提供组织，方向性和效果信息的信息。此外，可以通过REST Web服务访问所有MIPPIE数据和元数据，也可以将其下载为文本文件，从而有助于将鼠标PPI集成到后续生物信息学管道中。