Dual-Temperature-Responsive Microgels from a Zwitterionic Functional Graft Copolymer with Superior Protein Repelling Property,ACS Macro Letters

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Dual-Temperature-Responsive Microgels from a Zwitterionic Functional Graft Copolymer with Superior Protein Repelling Property
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-06-04 , DOI: 10.1021/acsmacrolett.0c00304
Pabitra Saha _{1,

2} , Marta Santi _{1,

2} , Martin Frenken ₁ , Anand Raj Palanisamy _{1,

3} , Ritabrata Ganguly ₃ , Nikhil K Singha ₃ , Andrij Pich _{1,

2,

4}

Affiliation

In this work, we developed a synthetic strategy to synthesize dual-temperature-responsive low surface fouling zwitterionic microgels. Statistical poly(N-vinylcaprolactam-co-glycidyl methacrylate) copolymers were synthesized by RAFT polymerization and post-modified by thiol-epoxy click reaction with thiol end-group-modified poly(sulfobetaine) macro-RAFT (PSB-SH) to obtain poly(N-vinylcaprolactam-co-glycidyl methacrylate)-graft-poly(sulfobetaine) (PVCL-co-PGMA-g-PSB) graft copolymers. Synthesized graft copolymers were cross-linked by diamine cross-linker in water-in-oil (w/o) inverse mini-emulsion to obtain zwitterionic microgels. Using this approach, we synthesized microgels with unique microstructure, high loading and uniform distribution of poly(sulfobetaine) chains, which exhibits tunable dual-volume phase transition temperatures. The microgels also showed excellent antifouling property reflected in strongly reduced protein absorption on a microgel-coated surface observed in real time by a Quartz Crystal Microbalance with Dissipation (QCM-D) monitoring experiment with continuous flow of protein solution. Therefore, this kind of zwitterionic microgel can be potentially used for temperature-triggered drug delivery and anti-bioadhesion coating material as well.

中文翻译：

由具有优异蛋白质排斥性能的两性离子功能接枝共聚物制成的双温度响应微凝胶

在这项工作中，我们开发了一种合成策略来合成双温度响应性低表面污染两性离子微凝胶。通过RAFT聚合合成统计聚( N-乙烯基己内酰胺-共-甲基丙烯酸缩水甘油酯)共聚物，并通过硫醇-环氧点击反应与硫醇端基改性的聚(磺基甜菜碱)大分子-RAFT(PSB-SH)进行后改性，得到聚( N-乙烯基己内酰胺-共-甲基丙烯酸缩水甘油酯)-接枝-聚(磺基甜菜碱)(PVCL-共-PGMA- g-PSB) 接枝共聚物。合成的接枝共聚物通过二胺交联剂在油包水（w/o）反相微乳液中交联，得到两性离子微凝胶。使用这种方法，我们合成了具有独特微观结构、高负载和均匀分布的聚（磺基甜菜碱）链的微凝胶，其表现出可调节的双体积相变温度。微凝胶还显示出优异的防污性能，这反映在通过石英晶体微量天平（QCM-D）在蛋白质溶液连续流动的情况下实时观察到的微凝胶涂层表面上的蛋白质吸收大大降低。因此，这种两性离子微凝胶也可以潜在地用于温度触发的药物递送和抗生物粘附涂层材料。

更新日期：2020-06-04

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