Lymphoma microenvironment is a dynamic and well-orchestrated network of various immune and stromal cells that is indispensable for tumor cell survival, growth, migration, immune escape, and drug resistance. Recent progress has enhanced our knowledge of the pivotal role of microenvironment in lymphomagenesis. Understanding the characteristics, functions, and contributions of various components of the tumor niche, along with its bidirectional interactions with tumor cells, is paramount. It offers the potential to identify new therapeutic targets with the ability to restore antitumor immune surveillance and eliminate the protumoral factors contributed by the tumor niche.

淋巴瘤微环境是由各种免疫细胞和基质细胞组成的动态且精心组织的网络，对于肿瘤细胞的存活，生长，迁移，免疫逃逸和耐药性是必不可少的。最近的进展增加了我们对微环境在淋巴瘤发生中的关键作用的认识。了解肿瘤小生境的各个组成部分的特性，功能和贡献，以及与肿瘤细胞的双向相互作用是至关重要的。它提供了潜在的机会，能够确定新的治疗靶点，并具有恢复抗肿瘤免疫监视和消除肿瘤生态位促成的肿瘤因子的能力。