Peripheral T-cell lymphomas represent an evolving class of aggressive T-cell malignancies that are generally refractory to conventional treatments and historically carry a poor prognosis. Recent advances in gene expression profiling have begun to unravel the specific molecular mechanisms of tumorigenesis in these disease processes, allowing for discrete classification schemes that help guide discussions regarding prognosis and therapy options. We outline here a review of the histopathology, epidemiology, clinical features, and treatment strategies currently used in the management of these diseases.

中文翻译：

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外周T细胞淋巴瘤的诊断，风险分层和治疗：过去和现在。

周围性T细胞淋巴瘤代表了不断发展的一类侵略性T细胞恶性肿瘤，通常对常规治疗无效，并且历史上预后较差。基因表达谱分析的最新进展已开始阐明这些疾病过程中肿瘤发生的特定分子机制，从而允许采用离散分类方案来帮助指导有关预后和治疗方案的讨论。我们在这里概述了目前用于治疗这些疾病的组织病理学，流行病学，临床特征和治疗策略。